Welcome to another blog post for the weekly nootropic ingredient spotlight series.
Today we are taking a look at Acteolin, which is the Osmanthus Fragrans Flower extract.
What is Acteolin?
Some interesting studies have shown that this extract contains nutrients and antioxidants that are able to support cognitive function as well as lung/respiratory health and eye health.
How does Acteolin work (Mechanisms of action)?
Acteolin or Osmanthus Fragrans Flower extract works primarily via the following mechanisms of action:
- Reduces β-amyloid peptide (Aβ) accumulation and abnormal tau protein phosphorylation
- Improves and protects cholinergic system in the brain (promotes Acetylcholine)
- Supports lung functions by reducing Nuclear factor Kappa B (NF-KB) induced inflammation, collagen accumulation and histamine release in lung tissuue
- Supports retinal functions by promoting hepatocyte growth factor (HGF) that may be involved in organ regeneration, would healing, embryogenesis and retinal pigment epithelium (RPE) that is essential for normal visual fucntions
Effects & Research for Acteolin?
The aging process in humans sometimes leads to a build up of a type of plaque in neuronal pathways called β-amyloid and Tau protein. The buildup or accumulation of β-amyloid is implicated in impaired cognitive and memory functions. Evidence suggests this may be a strong marker for Alzheimer's Disease.
One 2013 study by Manami Kurisu et al. showed that acteoside was able to inhibit B-Amyloid Aggregation in human neuroblastoma cells. This was achieved by enhancing expression of mRNA of glycolytic enzymes and intraceullular ATP. Acteoside also acts as an antioxidant that protected these human neuroblastoma (SH-SY5Y) cells against AB cell injury by protecting ROS production and modulating the apoptotic signal pathway.
Results from this study showed that Acteoside had strong inhibitory effects on AB aggregation and may therefore be a promising therapeutic option for inhibiting the AB42-mediated pathology in AD.
Another 2015 study showed that Osmanthus Fragrans Flower Extract, high in acteosides, successfully protected against d-Galactose-Induced aging in rodents. An aging ICR mouse model was administered d-galactose (250mg/kg) for 8 weeks. D-Galactose induced spatial learing and memory impairments which was successfully inhibited by OFE and acteoside.
In vitro and animal clinical studies have reasonably shown that acteosides like Acteolin can support cognition and memory through its affect on the cholinergic system and attenuation of B-amyloid and Tau protein.
We can't wait to see more human trials for Acteoside based compounds to explicitly determine it's neuroprotective effect and potential to benefit and support healthy aging. The current evidence however points to this being a very promising compound and pathway to prevent neurodegeneration over time.