Welcome to another blog post for the weekly nootropic ingredient spotlight series.
Today we are taking a look at Acteolin, which is the Osmanthus Fragrans Flower extract.
Acteolin or Osmanthus Fragrans Flower extract works primarily via the following mechanisms of action:
The aging process in humans sometimes leads to a build up of a type of plaque in neuronal pathways called β-amyloid and Tau protein. The buildup or accumulation of β-amyloid is implicated in impaired cognitive and memory functions. Evidence suggests this may be a strong marker for Alzheimer's Disease.
One 2013 study by Manami Kurisu et al. showed that acteoside was able to inhibit B-Amyloid Aggregation in human neuroblastoma cells. This was achieved by enhancing expression of mRNA of glycolytic enzymes and intraceullular ATP. Acteoside also acts as an antioxidant that protected these human neuroblastoma (SH-SY5Y) cells against AB cell injury by protecting ROS production and modulating the apoptotic signal pathway.
Results from this study showed that Acteoside had strong inhibitory effects on AB aggregation and may therefore be a promising therapeutic option for inhibiting the AB42-mediated pathology in AD.
Another 2015 study showed that Osmanthus Fragrans Flower Extract, high in acteosides, successfully protected against d-Galactose-Induced aging in rodents. An aging ICR mouse model was administered d-galactose (250mg/kg) for 8 weeks. D-Galactose induced spatial learing and memory impairments which was successfully inhibited by OFE and acteoside.
In vitro and animal clinical studies have reasonably shown that acteosides like Acteolin can support cognition and memory through its affect on the cholinergic system and attenuation of B-amyloid and Tau protein.
We can't wait to see more human trials for Acteoside based compounds to explicitly determine it's neuroprotective effect and potential to benefit and support healthy aging. The current evidence however points to this being a very promising compound and pathway to prevent neurodegeneration over time.
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You hear the word neurotransmitters pretty often. But do you actually know what they are?
Let's go over some theory.
Neurotransmitters are simply the body's chemical messengers. They come in the form of molecules used by the nervous system to transmit messages between neurons (e.g. nerve cells) or from neurons to muscles.
Calm Nootropic is first and foremost designed as a world-class sleep supplement. We do this by both increasing the quality of sleep, reducing the time taken to fall asleep (known as sleep latency) and also reducing the amount of awakenings throughout the night.
Calm includes 3 key ingredients which act to support sleep quality.
A big outcome for Calm Nootropic was to create a delicious product that is capable of reducing the noisy brain, increasing feelings of calm and improving mood at the end of a busy day.
Increasing "calming brainwaves" was done by adding 300mg of L-Theanine and improving mood is achieved primarily with the addition of 800mg of L-Tryptophan.