Neuratech

Enhance V2 Breakdown

Enhance V2 Breakdown | Neuratech

We launched Enhance V1 in April 2020 in the form of a 2-per day capsule product. This is what we have on the market currently. Our formula is potent, with some of the highest quality patented/trademarked ingredients in the world. It is an expensive formula, but you really are paying for what you’re getting here.

We are revamping Enhance now to be in a delicious powder format which will hopefully enhance the experience and be more compatible in your morning routine. We’ve added in a few ingredients and taken a few out.

We’ve removed and replaced the following: Synapsa Bacopa, Acteolin, Neurofactor, Cellcharge, CDP-Choline and Bioperine.

Acteolin is an extract of the Osmanthus Fragrans flower. It seems promising, but ultimately we’ve determined that we’d like to see more research on it, in particular human clinical studies. Also its primary mechanism of action (reduction of Beta Amyloid and Tau) doesn’t seem to hold too much weight as being a main cause of neurodegeneration or cognitive decline. 

We removed Neurofactor as it is being replaced by Hydrocurc + Iron as our main hard hitting ingredients for boosting Brain Derived Neurotrophic Factor (BDNF). We think having both targeting the same effect/mechanism may be an unnecessary combination and additional cost to the consumer. 

Cellcharge is a micronutrient liquid suspension that contains a variety of trace vitamins, minerals and fulvic acid to promote anti-oxidant and anti-inflammatory capability. We’ve replaced this with higher doses of more specific vitamins and micronutrients needed to support brain health primarily that are more often than not lacking in the modern, western diet.

CDP-Choline is now being replaced with Alpha-GPC. Alpha-GPC actually converts into acetylcholine more efficiently than CDP-Choline. We also want to add in Uridine Monophosphate in the future and think it would pair better with Alpha-GPC instead.

We’ve replaced Bioperine (Black pepper extract) with Astragin. Astragin seems to be a superior ingredient for absorption.

We’ve had to remove Synapsa Bacopa as it’s technically not approved for use in Australia, and opted in for Bacopin branded Bacopa Monnieri developed by Sabinsa Corporation. 

Enhance V2 Basics:

Format: Powder

Flavour: Vanilla Latte

Purpose: To provide the essential micronutrients for optimal long term brain health and to support neurons. To provide phytonutrients and natural extracts to further support and improve long term memory and learning. To provide neuroprotection and support healthy brain aging.

Who should use this product: Anyone 40+ looking to keep their brain healthy and help prevent cognitive decline through nutrition. Anyone else looking to perform at their cognitive peak or fix potential nutritional deficiencies that reduce brain performance.

Directions of use: Take 1 scoop daily with water or mix with your favourite shakes (protein/greens), smoothies, food or coffee.

Enhance V2 Ingredients: 

  • GoMCT powder (3g)
  • Lions Mane Mushroom (1g)
  • Alpha-GPC (600mg)
  • Hydrocurc (500mg) + Iron (18mg)
  • Algae Omega 3’s (500mg)
  • Bacopin Bacopa Monnieri (300mg)
  • Sharp PS Phosphatidylserine (100mg)
  • Vitamin C
  • Vitamin D
  • Vitamin B Complex
  • Astragin (50mg)

New Ingredients Breakdown:

goMCT®

goMCT is a patented form of medium chain triglycerides by our friends over at Compound Solutions. This form of MCT is a healthy fat that converts readily into ketones, an alternate energy source for the human brain and body. It also has the additional benefit of staving off hunger and potentially aiding in weight management. 

goMCT specifically contains C8 (caprylic acid) and C10 (capric acid) MCT’s as well as acacia fiber, a prebiotic that aids in gut health.

goMCT was used in Enhance V2 primarily as a source of healthy fat to help increase absorption of the fat-soluble ingredients and plant extracts found in this formula. It also has the additional benefit of giving a rich, creamy texture to the powder when mixed in water.

MCT’s are also a great source of ketones, which has some evidence showing it can help support long term brain health. In particular, the use of MCT’s or a high fat ketogenic diet to reach nutritional ketosis may have a modest beneficial outcome in mild to moderate Alzheimer’s Disease and in mild cognitive impairment [1].

Another major study found that MCT’s improved learning, memory and brain processing in people with mild to moderate Alzheimer’s disease. However, this was only observed in those who didn’t have the APOE4 gene variant. [2]

Alpha-GPC

Alpha-GPC (Alpha-glycerophosphocholine) is a choline containing supplement and precursor to Acetylcholine, a neurotransmitter responsible for muscular control and supporting memory and learning.

Alpha-GPC is the most efficient choline precursor to deliver choline to the brain following oral administration.

Choline on its own is found in many food sources, including in high quantities in eggs and meats. However, supplementing with a highly bioavailable form of choline such as Alpha-GPC does seem to show some additional benefit.

One study showed that Alpha-GPC was able to support cognitive improvement in mild to moderate Alzheimer’s dementia after a period of 90 days and 180 days in a variety of test scores. This was done at a dose of 1200mg per day. [3]

Another study showed that 1g/day of Alpha-GPC when injected intramuscularly for 90 days in 120 patients with mild to moderate vascular dementia, was able to produce definite symptomatic improvements. [4]

Hydrocurc + Iron

Hydrocurc is a cold water dispersible Curcuma longa (Curcumin) extract developed by Pharmako Biotechnologies. 

Hydrocurc uses a proprietary Lipisperse technolgy to help increase bioavailability of its curcuminoids. A study on humans showed that Hydrocurc was able to provide the highest amount of curcuminoids seen in industry to date from a single dose.

Curcumin is known to significantly affect human health, and in particular reduce high levels of inflammation and oxidative stress. Chronic/underlying stress and inflammation is known to promote disease in the body and is the cause for many unfortunate conditions in the modern world.

Iron is an essential mineral that is involved in several metabolic processes, such as blood production, oxygen transport and DNA synthesis. Iron deficiency is also the most common nutritional disorder worldwide, which can result in decreased physical and mental performance. Those most susceptible to iron deficiency include menstruating, pregnant or breastfeeding women and anyone who follows a vegan/vegetarian diet. 

The unique combination of Hydrocurc + Iron has shown a lot of promise recently and has been the center of a lot of research and clinical trials.

A new study, published in the highly regarded journal Antioxidants, looked at the co-administration of Hydrocurc and Iron for increasing Brain-derived Neurotrophic Factor (BDNF). This 6 week, randomised, double blind, placebo controlled study of 155 healthy adults, showed that a combination of 500mg Hydrocurc and 18mg Iron taken over 42 days was able to significantly increase BNDF levels.

 

BDNF levels expressed as percentage difference compared to baseline levels (From Hydrocurc + Iron study)

BDNF is a neurotrophin protein that plays a big role in neuron (brain cell) growth, repair and survival. BDNF is responsible for supporting cognitive function, learning and memory as well as energy metabolism in humans.

Algae Omega 3 DHA and EPA

Most know of Omega 3’s found in fatty fish or fish oil supplements.

In Enhance V2 we’ve opted to provide this essential nutrient through algae sources instead. It is a more sustainable source, and also a vegan friendly source of Omega 3's.

Omega 3’s include DHA, EPA and ALA. These are fatty acids found in high quantities in fatty fish, algae and several high fat plant foods.

Omega 3’s are hugely important in the human body as components of the phospholipids in cell membranes. DHA is particularly high in the retina, brain and sperm cells.

Most people do not consume enough fish or get enough sources of Omega 3 from their diet. If you consume fatty fish less than 2 times per week, or not at all, then you should consider supplementation with Omega 3 DHA/EPA. A dose up to about 500mg-1000mg per day seems to be beneficial.

Some observational studies suggest that diets high in omega 3’s are associated with a reduced risk of cognitive decline, Alzheimer’s disease and dementia.

DHA is an essential component of cellular membrane phospholipids in the brain and therefore may protect cognitive function by helping maintain neuronal function and cell membrane integrity.

Supplementing with additional Omega 3’s seems most beneficial for those suffering from mild cognitive decline that are approaching Alzheimer’s or Dementia, or those with depressive symptoms.

Bacopin Bacopa Monnieri

Bacopin is a patented extract of Bacopa Monnieri developed by Sabinsa.

It is specific extract that is standardised to 20% Bacosides — the main constituent compounds that provide its beneficial effects. This is different to the standardisation of other Bacopa extracts. For example, Synapsa Bacopa is standardised to 55% Bacosides. 

We’ve had to make the switch from Synapsa Bacopa to Bacopin as Synapsa is not technically allowed to be used in Australia unfortunately. However, both are super high quality, patented extracts that are tested for quality and safety. 

For those who don’t know, Bacopa Monnieri is an ancient herb that has been used for 100’s of years in Traditional Chinese Medicine and Indian Medicine (Ayurveda) as a brain health and memory tonic.

The primary mechanism and process for how Bacopa Monnieri and Bacopin in particular boosts memory is as follows:

  1. On receiving signals from the sensory organs, the receptors in each neuron of the hippocampus trigger an electric pulse, mediated through a change in protein composition
  2. The pulse is transmitted to the neuron through the synapse. The process continues until the bond between the neurons become strong and a memory is created
  3. However, continuous electrical activity wears out the synapses, impairing new memory creation causing a loss of memory
  4. The bacosides help in restoring the synaptic activity of neurons

To learn more about the other mechanisms of action for Bacopa Monnieri, and some of the landmark studies showing its efficacy please see our Bacopa Nootropic Ingredients Spotlight FULL BLOG HERE.

Astragin®

Astragin by NuLivScience is a patented ingredient combining two natural extracts from Panax Notoginseng and Astragalus Membranaceus.

It has been shown to increase the absorption of many vital nutrients such as amino acids, Omega 3s, creatine and even CBD.

It promotes a healthy gut lining and gut barrier integrity which leads to reduced inflammation in the intestinal lining. 

There have been a total of 16 in-vitro (test tube/cell model) studies and 8 in-vivo (animal/human) studies on Astragin. These studies have shown that Astragin has the following mechanism s of action:

  • Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up-regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4.*
  • Rejuvenate ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation.* AstraGin® was shown in a hematoxylin-eosin stain and an MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and submucosal edema in TNBS-induced colitis rats.
  • Support the digestive system by maintaining a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate.*
  • Helping support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut-associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages.

The recommended dose for Astragin is 50mg and that is the amount we use in Enhance V2.

Vitamin C

Vitamin C, or ascorbic acid is a water soluble vitamin (dissolves in water), and isn’t stored well so must be taken in from food or supplements.

Vitamin C is a powerful antioxidant that neutralizes free radicals and is required for adequate nervous system, immune health and is needed to create collagen in the body.

In relation to brain health, Vitamin C has a significant role in modulating neurotransmitter synthesis and release in the brain.

This includes acting as a co-factor for dopamine beta hydroxylase in the conversion of dopamine to noradrenaline, involvement in the modulation of both dopaminergic and glutamatergic neurotransmission, and regulation of catecholamine and acetylcholine release from synaptic vesicles. 

Being deficient in this vitamin can impact your brain health and may even increase depressive symptoms.

Thankfully, most people in the Western world will not be deficient in this vitamin. While we do get a lot from our diet, supplementing more to ensure optimal function is very safe.

In particular, Vitamin C seems like a promising therapeutic aid (as an antioxidant) for neurodegenerative disease due to the involvement of Reactive Oxygen Species in the pathogenesis of these diseases. 

Vitamin D

Vitamin D is often referred to as the “sunshine vitamin” as it is produced in the skin is response to sunlight. 

It is a fat-soluble vitamin in a family of compounds that includes Vitamin D1, D2 an D3.

Vitamin D deficiency is fairly common, especially for those who don’t see enough sunlight. This is why it can be important to supplement with.

Vitamin D is needed for strong bones, muscles and overall health. It also controls the calcium levels in your blood. 

Vitamin D can have a significant effect on brain health too. Scientists have linked a deficiency of the hormone-like vitamin to some brain disorders like cognitive impairment, dementia, psychosis and autism.

Not only this, but the elderly population has a much higher risk for Vitamin D deficiency due to decreased endogenous production and low dietary intake of vitamin D. 

Vitamin D receptors are widespread in brain tissue, and vitamin D’s biologically active form has shown neuroprotective effects.

Lions Mane Mushroom

To learn about Lions Mane Mushroom, check out our ingredients spotlight here.

Sharp PS Phosphatidylserine

To learn about Sharp PS Phosphatidylserine, check out our ingredients spotlight here.

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