Welcome to another blog post for the nootropic ingredient spotlight series.
Today we are taking a look at a new, exciting nootropic compound called Neurofactor® .
What is Neurofactor®?
Neurofactor is an all natural, patented extract of whole fruit from the Coffea Arabica plant, developed by our friends over at Futureceuticals.
Neurofactor contains an interesting profile of polyphenols (plant micronutrients and anti oxidants) that have been shown, through clinical trials, to improve and stimulate the production of Brain-Derived Neurotrophic Factor (BDNF), a key neuro-protein that helps support neurons and brain health within humans.
Neurofactor is found in our own product, Enhance Nootropic, at a dose of 100mg.
Let's look at why we thought this was a useful inclusion in our potent brain health & memory formula.
How does Neurofactor ® work (Mechanisms of action)?
As we stated above, the current primary mechanism of action, as verified via 2 published clinical trials is:
1. Increased production/stimulation of BDNF
This leads to a host of downstream effects, which can include:
- Modulating neurotransmitters
- Increasing neuronal plasticity
- Increasing expression of pro survival genes
- Regulating glucose and energy metabolism
BDNF is a key protein active in the brain and central and peripheral nervous systems with a critical role in neuron development, repair, maintenance and in protecting against neuro-degeneration.
Decreased levels of BDNF has been associated with certain neurodegenerative diseases, such as Alzheimer's, Multiple Sclerosis (MS) and Huntington's disease.
Effects & Research for Neurofactor ®
There have been two published clinical trials looking at the effects of Neurofactor on the human body.
In one double-blind, placebo-controlled pilot human clinical study, NeuroFactor™ increased plasma levels of Brain-Derived Neurotrophic Factor (BDNF) by 143% on average. No significant increases in BDNF were seen from green coffee bean extract, grape seed extract and green coffee caffeine powder.
This study was performed using 100mg of Neurofactor™ (Whole coffee fruit extract), and this is the exact dose we are mimicking in our formula for Enhance.
In another placebo controlled study, 20 healthy subjects, of 25-35 years of age, were given a single dose of Neurofactor (Whole Coffee fruit extract), and within 60 minutes, showed a statistically significant increase in plasma BDNF (91% increase at 60 minutes). This came down to a 66% increase at 120 minutes as compared to baseline. This result was not seen with ingesting freshly brewed coffee.
Neurofactor™ shows some really great promise in increasing plasma levels of BDNF. However, we would love to see studies done on a larger cohort of participants. We would also love to see some studies showing whether this increase in BDNF produced any noticeable improvements in memory scores and other cognitive assessments.