Ingredients & Research

Unlike other nootropics which focus on one or two aspects of cognition (memory, focus etc.), Claritea has been specifically designed to provide both immediate and long term cumulative benefits with ongoing use. Consequently, Clartiea is an effective tool for those looking to increase their cognitive function, no matter the goal.

 

Design Philosophy

 

Claritea is one of the most effective Nootropic formulations on the market! 

How did we achieve this? Simple.

This product was designed following a strict set of principles, which enabled us to create a formula that we are confident enough to share with the world.

 

    1. Provide only extensively researched ingredients, that are proven to be both safe and effective.​
    2. Include ingredients that improve both short and long term aspects of cognition.​
    3. Utilise the proper (researched) dosages for each ingredient for the most effective results.

 

Manufacturing Note

 

To ensure that our products are effective, safe, and consistent we follow three key principles at Neuratech:

    1. We source, test, and use only the highest quality ingredients from the best suppliers who comply with all Australian production and testing requirements.
    2. Our products are only produced by the best manufactures who exceed the Australian manufacturing requirements and provide continued, safe, and reliable manufacturing capabilities.
    3. Our ingredients and products are independently assessed to ensure safety and consistently at two key points throughout the production process. Firstly, all ingredients are analysed for quality upon delivery and secondly, a representative sample is taken of the final product prior to release to the public.

 

Ingredients

 

Although we spent a considerable amount of time researching our ingredients and determining the most effective doses we believe in 100% transparency and don't hide behind proprietary blends. We tell you exactly what you are getting.

  • Caffeine (100mg)
  • L-Theanine (200mg)
  • Vitamin B6 (5mg)
  • Vitamin B12 (0.01mg)
  • Alpha GPC (600mg)
  • Acetyl-L-Carnitine (1000mg)
  • L-Tyrosine (1000mg)
  • Rhodiola Rosea SHR-5 Extract (125mg)
  • Huperzine A (0.08mg) 

 

All of our incredible ingredients are backed by thorough scientific evidence supporting their effectiveness, but don't just take our word for it. We've compiled the most up to date research on each of our ingredients to showcase their effectiveness. If you want to fully understand the potential of nootropics then use the below information as a starting point for your research.

 

 

Caffeine (100mg)

Nootropic effects: As a result of it's multiple actions, caffeine is able to deliver energising effects to both body and mind by:

  • Suppressing “calming” brain chemicals: Caffeine blocks the effects of adenosine (a neurotransmitter) that promotes relaxation and decreases mental fatigue. 
  • Boosting “excitatory” brain chemicals: Caffeine increases the secretion of adrenaline which is responsible for the "fight or flight " response, as well as dopamine which is strongly related to motivation. Together this creates an alert & energized mindset. Caffeine effectively reduces fatigue, increases alertness and improves reaction time, motor response and short term memory formation.

Clinical studies:
Caffeine has been extensively studied and consistently demonstrates its powerful nootropic effects. Several studies have been selected that highlight caffeine's beneficial effects.
This review of more than 40 studies on caffeine identified several key benefits of caffeine, as follows:
1. Caffeine, in doses up to approximately 300 mg (∼4 mg kg−1), enhances a wide array of basic cognitive functions with minimal side effects by preventing alertness and attention decrements associated with suboptimal arousal.
2. The ability of caffeine to enhance cognitive and physical function is dose-dependent. Doses of approximately 0.5–4.0 mg kg−1 (∼40–300 mg) can improve cognitive function in rested individuals, whereas doses of 3–7 mg kg−1 (∼200–500 mg) ingested approximately 1 h prior to exercise can enhance physical performance.
3. Caffeine is an effective strategy to counter both physical and cognitive degradation associated with sleep loss.
This double-blind, randomized, placebo-controlled study investigated the individual and combined effects of caffeine 150 mg and L-theanine 250 mg on visual processing accuracy, simple reaction time, numeric working memory reaction time and sentence verification.

Researchers reported that caffeine seemed to boost mental performance leading to “faster digit vigilance reaction time” and “improved Rapid Visual Information Processing (RVIP) accuracy” Caffeine also led to better self-rated mental fatigue scores.

 

L-Theanine (200mg)

L-Theanine (Theanine) helps to increase alpha brainwave activity, which is strongly associated with enhanced creativity and wakeful relaxation. It increases the production and activity of ”calming” neurotransmitters like serotonin, dopamine and GABA while controlling the effects of ”stimulatory” neurotransmitters such as adrenaline. It may also be potentially helping in preventing mental decline usually associated with ageing.
Nootropic effect:

  • Promoting relaxation: Theanine is largely responsible for the calm and tranquil feeling associated with tea consumption.
  • Enhancing alertness: Theanine has been consistently shown to improve alertness, focus, and attention.
  • Reducing anxiety: Theanine helps reduce anxiety and stress by promoting calming brain chemicals such as GABA.
  • Neuroprotection: Theanine may help protect brain cells from damage, such as that seen in age-related cognitive decline.
Synergy with Caffeine: On it's own L-theanine is a powerful nootropic but when paired with caffeine or other stimulants its calming effects are able to take the edge off of the stimulant and allow for a smoother, more controlled mental state.
Clinical Studies:
L-theanine has been extensively studied in humans with results showing numerous beneficial effects. The key findings of several studies are listed below.
 
 

Vitamin B12 (10mcg)

Vitamin B12 is an essential vitamin with many key roles in the maintaining normal function of the central nervous system (CNS). B12 is able to promote the following nootropic benefits:

Nootropic effect:
  • Energy production: B12 is vital for many processes related to the creation, transportation and utilisation of energy for cellular activities.
  • Supporting CNS health: B12 is involved in numerous essential processes of healthy brain function including the creation and maintenance of mylen sheaths (insulation for nerve cells) which allows the effective transmission of nerve signals.
  • Promoting healthy brain aging: B12 levels naturally decline as we age, and may be linked to age-related cognitive dysfunction.
  • Stress regulation: B12 is heavily involved in reducing oxidative stress and B12 deficiency has been linked to stress related disorders such as depression.
​​
Clinical Studies:
The objective of this study was to investigate the relationship between vitamin B12 status and brain volume loss per year over a 5-year span in an elderly population. One hundred and seven volunteers (aged 61 to 87 years) without cognitive impairment were assessed for their blood B12 levels and associcated molecules, such as transcobalamin (TC) and homocysteine (tHcy). The study found that individuals with lower baseline vitamin B12 and holoTC levels experienced a greater loss of brain volume.
The conclusion from this work was that “low vitamin B12 status should be further investigated as a modifiable cause of brain atrophy and of likely subsequent cognitive impairment in the elderly”
This study examined the structural and functional changes in the brains of patients with B12 deficiency, and the effects of B12 supplementation. Sixteen people with B12 deficiency were tested before and after 6 weeks of vitamin b12 therapy (1000 micrograms daily, then weekly, and finally monthly); supplementation lead to the significant recovery of the initially impaired cerebral blood flow and improvement of basic neuropsychological functions.
The researchers concluded that “micro-structural recovery lags behind functional recovery in patients with vitamin B12 deficiency following therapy and CBF change may be used as an early predictor of complete recovery in patients with B12 deficiency“.
 

Rhodiola Rosea (125mg)

 

Rhodiola Rosea is an adaptogenic herb that has been used in traditional Russian and Scandinavian medicine for hundreds of years. Hundreds of active compounds have been identified in Rhodiola, the most important being Salidroside (Rhodioloside) and Rosavin, which are thought to be responsible for its nootropic benefits.
Nootropic effect:
  • Reduces Stress and Fatigue: Rhodiola Rosea helps increase energy, alertness and stamina while reducing stress and fatigue. It is also known for its ability to improve mental performance under periods of prolonged stress. Research shows Rhodiola Rosea can increase attention to detail-oriented tasks by improving concentration over extended periods. This makes Rhodiola ideal for long periods of study or mentally challenging task.
  • Improves Mood: Rhodiola Rosea supports serotonin, norepinephrine and beta-endorphins (feel good hormones) levels in your brain. Together this results in a stimulated and pleasant mood that is conducive to stress free productivity.
  • Neuronal Protection and Regeneration: Rhodiola Rosea and its active compounds such as salidroside protects existing neural cells and aids neurogenesis by reducing oxidative stress and inflammation. It also increases the synthesis and re-synthesis of ATP, the energy source of all cells and cellular reactions.
  • Cognitive Enhancement: Research and clinical trials have indicated in independent settings that Rhodiola significantly increases certain aspects of cognition including; motivation, memory (short and long term), concentration, perceptive speed and capacity for mental work.

Clinical Studies:
While research into the effects of Rhodiola are still in their growing, the current body of knowledge indicates promising findings.
Rhodiola extract WS(R) was given to individuals (n=101) with significant symptoms of life-stress at a dose of 200 mg twice daily for 4 weeks. A number of stress and psychological well-being questionnaires were administered to the participants throughout the study.
The results showed that stress symptoms, fatigue, quality of life, mood, and concentration all showed consistent improvement after 3 days of treatment, and continued improving after weeks 1 and 4.
The researchers concluded that “Rhodiola extract at a dose of 200 mg twice daily for 4 weeks is safe and effective in improving life-stress symptoms to a clinically relevant degree“
This randomized, double-blind study examined the therapeutic effects of SHR-5 Rhodiola rosea root extract in people with stress-related fatigue. Sixty people were randomly assigned to a placebo or SHR-5 (576 mg, daily) group for 4 weeks.
Both groups saw improvement in several stress related measures including fatigue, depression, attention, and self-reported mental health. However, the Rhodiola group showed a statistically significant improvement in symptoms of fatigue and attention performance compared to the placebo group.
The researchers concluded that “R. ROSEA extract SHR-5 exerts an anti-fatigue effect that increases mental performance, particularly the ability to concentrate, and decreases cortisol response to awakening stress in burnout patients with fatigue syndrome“
One hundred and sixty one cadets between the ages of 19 and 21 were randomly split between three groups (a placebo, 370mg or 555mg of Rhodiola extract SHR-5. The cadets were tested after a single dose for a variety of fatigue related psychometric factors. All groups showed improvement in anti-fatigue index testing, but the Rhodiola groups was found to have significantly greater improvements compared to the placebo group. The researchers also noted that there was no difference in anti-fatigue effects between the rhodiola groups.
The researchers concluded that “There was a possible trend in favour of the lower dose in the psychometric tests… No such trend was found in the physiological tests.”​
 

Huperzine (80mg)

 

Huperzine A is a natural compound and main active ingredient of Chinese club moss (Huperzia serrata) that readily crosses the blood brain barrier. It is used to treat neurodegenerative diseases such as Alzheimer’s disease and is well known for its ability to improve memory and cognitive abilities whilst also protecting the brain from oxidation stress and inflammation.
Nootropic effect:
  • Boosts acetylcholine: Huperzine A blocks an enzyme that destroys acetylcholine, leading to higher levels within the brain. Acetylcholine is an essential neurotransmitter that is highly involved in memory formation, motivation and overall brain signalling. As a result, increased levels of acetylcholine can aid memory formation, cell signalling and overall brain function.
  • Raises energy levels and fights fatigue: Huperzine A supports mitochondrial activity leading to increased levels of ATP (cellular energy), for all areas of the brain.
  • Promots nerve growth factor (NGF): Studies show that Huperzine A increases NGF which is essential for neuroplasticity, aswell as overall brain health and function.
  • Protects brain cells: Huperzine A is an antioxidant that boosts activity of other brain antioxidants as well as reducing cellular inflammation.
Clinical Studies:​
Eight clinical trials on Alzheimer’s (AD, 733 participants) and two clinical trials on vascular dementia (VD, 92 participants) were undertaken individually to test the potential effects of Huperzine A. Overall, improvements were seen in subjective measures of general living in both AD and VD patients as well as improved cognitive performance (especially memory). The strength of the effect was strongly correlated with longer duration's of supplementation, especially within the AD group.
Researchers concluded that Huperzine A is a well-tolerated treatment “that could significantly improve cognitive performance in patients with AD or VD.”
A double-blind controlled study of 34 pairs of middle-school and junior-high students with self reported memory problems were given either 100 mcg Huperzine A or placebo daily for 4 weeks. After analyzing the results, students who had taken Huperzine A performed significantly better on Memory Quotient testing than the placebo group.
Researchers concluded that Huperzine-A “enhanced the memory and learning performance of adolescent students.”
In this study, 103 Alzheimer’s patients were given either 200 mcg of Huperzine A or a placebo daily for 8 weeks. Over the course of the study subjects were undertook several cognitive tests that measured factors including dementia ratings, mental wellness, mood and daily activity performance. Overall, 58% of the patients taking Huperzine A showed significant improvements in memory and cognition.
 

L-Tyrosine (1000mg)

 

L-Tyrosine is an amino acid used in the synthesis of proteins throughout the bodies. As a nootropic, L-Tyrosine effectively reduces stress and promotes healthy brain chemistry for alertness and peak mental performance.
Nootropic effect:
  • Reduces negative stress response: Tyrosine suppresses the production of cortisol and restores brain chemicals (dopamine, norepinephrine, epinephrine) that are depleted by stress.
  • Increased neurotransmitter production: Tyrosine is a precursor and readily utilised to produce norepinephrine, dopamine, and epinephrine.
  • Mental performance: Tyrosine supports cognition, mood and memory, especially during sleep deprivation and exposure to environmental stressors.​
Clinical Studies:​
​​
In one double-blind, placebo-controlled study, 19 volunteers underwent testing on three different days, first consuming 150 mg of L-Tyrosine per kilogram body weight or a placebo. Subjects were then immersed in 35 degrees Celsius or 10 degrees Celsius water for 90 minutes, during which they were tested for mental performance and stress hormones. Results revealed the tyrosine group performed better on memory tests, requiring less time to retain knowledge.
Researchers concluded these results are “indicative of more rapid and accurate information processing,” and suggested that supplemental tyrosine appears to improve working memory during the cold exposure that would typically “degrade cognitive performance.“
In a double-blind, placebo-controlled, crossover study, researchers investigated if supplementing subjects with 100 mg of tyrosine per kg of body weight might help their stress responses when exposed to cold and hypoxia (low oxygen levels) for 4.5 hours.
Researchers reported that tyrosine supplementation “significantly decreased symptoms, adverse moods, and performance impairments” in subjects with average or above-average stress responses. Researchers suggested that tyrosine be considered for “a variety of acutely stressful situations.”
In this placebo-controlled study, 16, young, healthy volunteers took 100 mg of tyrosine per kg of body weight and a placebo on separate days. On each day, the study subjects were tested on stress-sensitive tasks while being exposed to stressful 90 decibel sounds.
Researchers reported that tyrosine appeared to “improve (mental) performance on two cognitive tasks,” with benefits apparent one hour after taking the supplement. Tyrosine failed to influence mood in any way.
In this randomized, placebo-controlled, double-blind study, 19 female volunteers were given 2 g tyrosine or placebo prior to the N-back test, a measure of mental performance that is split into two levels of mental difficulty. While Tyrosine failed to reach significance in the easier test, in the harder test it was associated with significant reductions in “false alarms” and significant improvements in “correct rejections.”
Researchers reported the results “reinforces our suspicion that only tasks with considerable cognitive demands benefit from Tyrosine.” They further suggested that even though research is early, “Supplementation of Tyrosine may promote cognitive enhancement in inexpensive, efficient and healthy ways.“

A double-blind, placebo-controlled trial examined two groups (tyrosine and placebo) of volunteers who were kept awake for a period of 24 hours and took a battery of tests measuring their mood and mental performance: At the 6-hour mark, the tyrosine group received 300 mg tyrosine in two 150 mg doses. The tyrosine group performed significantly better on measures of wakefulness and mental performance when compared to the control group.
The researchers concluded that “tyrosine may prove useful in counteracting performance decrements during episodes of sustained work coupled with sleep loss.”
 

Acetyl-L-Carnitine (1000mg)

 

Acetyl-L-Carnitine (ALCAR) is an amino acid that supports health across many body systems and is able to cross the blood brain barrier where it can assist with many biological processes. ALCAR's main nootropic effects include:
Nootropic effect:
  • Neurotransmitters production and nerve signalling: ALCAR is a necessary precursor for acetylcholine and also promotes nerve transmission of other brain chemicals.
  • Increases energy levels: ALCAR supports mitochondrial membranes and asists in clearing "cellular waste", helping to support peak cell energy.
  • Neuroprotective effects: Preliminary evidence suggests ALCAR has neuro-protective and antioxidant. In addition, it has been shown to promote nerve growth factor (NGF1) and boosts brain circulation.
Clinical Studies:​
This meta-analysis reviewed and combined the results of 21 randomized controlled trials on ALCAR in a total of 1,204 patients (591 who had taken ALCAR, 613 who had taken placebo). Analysis of the results indicated that ALCAR had significant effects on attention, memory, mental performance and higher cognitive functions.
Researchers concluded that ALCAR “improved mild cognitive impairment,” reduced brain deterioration, and suggested taht ALCAR should be considered as a therapy for brain degeneration.
In this study, ALCAR or placebo was given to 130 Alzheimer’s patients daily for a year. The participants were tested against 14 different measures of cognitive performance. Overall, the ALCAR group’s mental decline was significantly slower than the placebo group’s in 13 of the 14 measures of performance.
Researchers concluded the ALCAR group “showed better scores on all outcome measures,” noting significant differences in intelligence, verbal, long-term memory and selective attention performance.
 

Alpha-GPC (600mg)

 

Alpha GPC (Alpha Glycerylphosphorylcholine) is a natural choline-containing compound. Alpha GPC is the most bio-available form of choline on the market. Alpha GPC has both a host of its own nootropic benefits and increases the effects of many other nootropics. It's nootropic benefits are the result of its choline supplementation as follows:

Nootropic effect:
  • Improved memory: Alpha GPC stimulates the release of acetylecholine which is responsible for memory storage and recall.
  • Brain health: Alpha GPC is used as an effective therapy for prevention of age-related and trauma-induced cognitive disorders. Choline is also a major component of cell membranes and helps to maintain cell health as well as promote cell growth.
  • Supporting the action of other nootropics: Many other nootropics either directly or indirectly utilise choline. As a reuslt, Alpha GPC provides the additional choline required for other nootropics to work as effectively as possible.
Clinical Studies:
This randomized study evaluated the effects of alpha GPC on memory impairment caused by the drug scopolamine. Thirty-two young, healthy participants were assigned to placebo or alpha GPC treatment for 10 days, after which they were given scopolamine or placebo on the 11th day and underwent cognitive tests. The study showed that alpha GPC countered the impairment causaed by scopolamine.
The researchers concluded that alpha GPC” is able to antagonize impairment of attention and memory induced by scopolamine“
This randomized study evaluated blood choline levels in 12 healthy adults after taking alpha GPC intravenously. Choline levels were compared in three phases: a control day without any drug; 1,000 mg alpha GPC for phase 2; and in phase 3, 1,000 mg Citicoline (CTC), which is also a precursor to choline and was used for comparative purposes. This study’s results showed a rise in choline levels with both alpha GPC and CTC, peaking at 0.25 to 0.5 hours after injection, with a decline to near baseline after 6 hours. However, choline levels were significantly higher with alpha GPC than CTC.
The researchers concluded that “After the administration of CTC, plasma choline levels showed a similar time course but were considerably lower than those observed after the administration of alpha-GPC“
 

Vitamin B6 (5mg)

 

Vitamin B6, also known as pyridoxine, is an established nutrient for overall wellness. Of its many health-supportive functions in the body, three in particular address brain health and mental performance:
Nootropic effect:
  • Neurotransmitter support: B6 is essential for the production of many neurotransmitter which helps establish and maintain optimum levels to promote brain function and regulate memory & mood.
  • Brain circulation: B6 fights homocysteine that slows circulation & cognition
  • Neural support and neurogenesis: B6 is directly involved in the growth processes of new neurons, neural (mylen) sheaths & neural connections.
Clinical Studies:
A review of B6 research identified that low B6 levels has been linked to decreased levels of neurotransmitters in humans. Subsequently, B6 supplementation is believed to restore neurotransmitter levels which may reverse associated effects such as stress, brain fog, mental fatigue and sadness.
The review's authors suggested that “high intakes of pyridoxine may have the potential to improve [cognitive & mood] in many individuals.”
​Researchers concluded that B6 Supplementation can increase verbal fluency and improve both long and short term memory.

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