Research & Ingredients

Design Philosophy 

    1. Provide only extensively researched ingredients, that are proven to be both safe and effective.​
    2. Utilise the proper, clinically validated dosages for each ingredient for the most effective results.
    3. Less is more. We aim to use a smaller number of ingredients for our formulas, but ensure each ingredient is potent in its efficacy, and is supplied at the correct dose. We use ingredients which only specifically contribute to the goals of each product (e.g. Enhance = Memory, Learning, Neuroprotection)
    4. No proprietary blends. Full label disclosure.

 

Manufacturing Note

 

To ensure that our products are effective, safe, and consistent we follow three key principles at Neuratech:

    1. We source, test, and use only the highest quality ingredients from the best suppliers who comply with all Australian production and testing requirements.
    2. Our products are only produced by the best manufactures who exceed the Australian manufacturing requirements (FSANZ & TGA approved) and provide continued, safe, and reliable manufacturing capabilities.
    3. Our ingredients and products are independently assessed to ensure safety and consistently at two key points throughout the production process. Firstly, all ingredients are analysed for quality upon delivery and secondly, a representative sample is taken of the final product prior to release to the public.

Enhance Ingredients

Although we spent a considerable amount of time researching our ingredients and determining the most effective doses we believe in 100% transparency and don't hide behind proprietary blends. We tell you exactly what you are getting.

  • Bacopa Monnieri (Synapsa) - 300mg
  • Cognizin Citicholine - 300mg
  • Lions Mane Mushroom - 500mg
  • Neurofactor (Whole coffee fruit extract) - 100mg
  • Acteolin - 200mg
  • Phosphatidylserine - 100mg
  • Cellcharge - 10mg
  • Bioperine - 10mg

All of our incredible ingredients are backed by thorough scientific evidence supporting their effectiveness, but don't just take our word for it. We've compiled the most up to date research on each of our ingredients to showcase their effectiveness. If you want to fully understand the potential of nootropics then use the below information as a starting point for your research.

 

Bacopa Monniera - Synapsa (300mg)

Nootropic effect:
  • Increased memory formation and free memory recall 
  • Increased measures of subjective well being
  • Decreased subjective measures of anxiety
  • Anti-oxidant and anti-inflammatory activity

Summary:

Bacopa or Brahmi is a herb native to the wetlands of southern and Eastern India, Australia, Europe, Africa, Asia and America.

Bacopa contains numerous compounds called Bacosides which contribute to its potent, memory and brain enhancing effects.

There are studies that show that supplementing 150mg of standardized extract of Bacopa called Bacognize, twice daily, over a period of six weeks provided statistically significant improvements in cognitive function.

Bacopa is proven specifically to improve memory in multiple studies, and is a very well known and respected cognitive enhancer.

Bacopa acts through a variety of potential mechanisms that contribute to its neuropharmacology, such as:

  • anti-oxidant neuroprotection (via redox and enzyme induction)
  • acetylcholinesterase inhibition and/or choline acetyltransferase activation
  • β-amyloid reduction
  • increased cerebral blood flow
  • neurotransmitter modulation (acetylcholine [ACh], 5-hydroxytryptamine [5-HT], dopamine [DA])

Bacopa is one of few very well studied nootropic compounds. For this reason, it is one of our flagship ingredients in our daily neurovitamin, Enhance.

Be weary, however, anecdotally some users report to have reduced feelings of motivation after consuming Bacopa. This may be due to the fact that some standardized extracts contain higher amounts of Serotonin Active Bacopa Glycosides (SABG’s) which may contribute to higher serotonin and thus give a more calming effect.

We are controlling/countering this in our Enhance Nootropic by utilising the Synapsa brand of standardised Bacopa extract, and also suggesting that the dosage be split to morning/night.

Cognizin Citicholine (300mg)

Nootropic effect:
  • Improved memory: CDP-choline is used to increase levels of  acetylcholine which is responsible for memory storage and recall during periods of high demand (e.g. mentally demanding tasks).
  • Activating the biosynthesis of structural phospholipids in the neuronal membranes
  • Increasing cerebral metabolism 
  • Acting on the levels of various neuotransmitters

Summary:

Cognizin Citicoline is a patented form of Citicoline, otherwise known as CDP-choline and is the most bioavailable form of choline available. Supplemental  Citicholine/CDP-Choline is broken down into choline, the precursor to Acetylcholine (the learning neurotransmitter) and cytidine in the intestines so that is able to cross the blood-brain barrier. Once these cross the Blood-brain barrier the body uses them to reform citicoline where it can be used by the brain..

 

Citicholine is a water soluble molecule, with more than 90% oral bioavailability. Peak plasma levels occur one hour after oral ingestion. Doses of up to 2000mg have been observed in humans and animals without causing any toxicity.

Supplementation with citicoline can increase the amount of choline available for acetylcholine synthesis and aid in rebuilding membrane phospholipid stores after depletion.

Both in animals and in human beings, citicoline has been shown to possess proved neuroprotective properties.

In clinical practice, a number of different studies have clearly shown that citicoline is "effective in cognitive impairment of diverse etiology, cerebrovascular disease, head trauma, glaucoma, amblyopia, and Parkinson’s disease (PD)"

The usual daily therapeutic dosage of citicoline in humans is 500–2,000 mg. We have opted in for 300mg per serve to ensure that no negative side effects become largely present which can occur with higher doses. High doses of choline sources are known to cause headaches.

Citicoline has a lot of promising clinical data to back its efficacy, particularly for those suffering from brain impairments. We think this is an essential nutrient to supplement with if you really want to preserve your brain over the long term, and minimise neurodegeneration due to aging or disease.

Studies:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562749/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933742/
  3. https://www.ahajournals.org/doi/pdf/10.1161/01.STR.30.12.2592
  4. https://clinicaltrials.gov/ct2/show/NCT03369925

Lions Mane Mushroom (500mg)

Nootropic effect:
  • Overall Neuro-protection (reduce cogntive decline or neurodegeneration)
  • Production of Nerve Growth Factor (NGF) to repair/grow neurons

Summary:

Lions mane mushroom (Hericium Erinaceus) is a medicinal mushroom native to North America, Europe and Asia. It is the mushroom most associated with improving brain function and so I think its hugely important to talk about.

Lions mane contains a number of natural compounds called polysaccharides such as Beta Glucans and Heteroglucans which have very beneficial effects.

There is clinical research showing that Lions Mane is able to promote the synthesis of neurotrophins such as Nerve Growth Factor (NGF) in cell models. This protein helps neuronal growth and repair. [1]

Also, rodent models show that Lions mane mycelium “ enriched with its active compounds is capable of delaying neuronal cell death in rats with neurodegenerative diseases, such as ischemic stroke, Parkinson’s disease, Alzheimer’s disease, and depression”.

Lions mane shows quite some promise for those suffering from mild cognitive impairment, with one study showing significant improvements in cognitive scores over a 16 week period. The participants all took 3g of Lions mane per day.

Lions mane has some really promising initial clinical data, but we would love to see more studies on healthy humans.

The most common dose we see anecdotally for Lions mane mushroom seems to be around 500mg-1g per day, whether this confers the same benefit as 3g is yet to be confirmed.

Other notable mushrooms: Reishi, Cordyceps, Turkey tail.

 

 

Phosphatidylserine - Sharp PS Green (100mg)

Nootropic effect:
  • Cell signalling - supports myelin surrounding neurons
  • Supports long term memory formation 
  • Staves off neurodegeneration 

Summary:

Phosphatidylserine is a phospholipid and key component of cell membranes.

It plays an important role in cell signalling, and is required for healthy nerve cell membranes and myelin (the fatty sheath that surrounds and protects neurons, providing insulation and allowing electrical impulses to travel between them).

Phosphatidylserine can be found both in animal products (meat, fish etc.) as well as vegetables (white beans and soy lecithin). Most supplements containing

Phosphatidylserine are derived from soy due to possible infectious disease from animal based products.

Sharp-PS Green is a patented form of Phosphatidylserine that has achieved GRAS status from the FDS and is derived from natural sunflower lecithin, free from soy. This is the form of Phosphatidylserine used in Enhance at a dose of 100mg/serve.

Clinical evidence shows Phosphatidylserine has efficacy in improving memory scores in the elderly over a 6 week period (at a dose of 100-300mg/day).

Phosphatidylserine may play a big role in staving off neurodegeneration, and supporting short term and long term memory formation. This nutrient is essential to our cells and it would be wise to supplement with if you're not taking in enough from your diet.

Studies:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981104/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966935/

Neurofactor - Whole coffee fruit extract  (100mg)

Nootropic effect:
  • Stimulates Brain-Derived Neurotrophic Factor (BDNF) to support neuronal growth/function

Summary:

Neurofactor is a really unique ingredient we are so excited to include in our formulation for Enhance. We are one of few companies in Australia supplying this within our products, yippee!

Neurofactor
 is a patented extract of whole fruit from the Coffea arabica plant. 

Neurofactor
 contains a unique profile of polyphenols that have been clinically proven to stimulate the production of Brain-Derived Neurotrophic factor (BDNF).

BDNF is a type of neurotrophin, which is a class of proteins responsible for the repair, maintenance and growth of neurons, as well as protection from neurodegneration (due to aging or disease).

In a double-blind, placebo-controlled pilot human clinical study, NeuroFactor
 increased plasma levels of Brain-Derived Neurotrophic Factor (BDNF) by 143% on average. No significant increases in BDNF were seen from green coffee bean extract, grape seed extract and green coffee caffeine powder. 

This study was performed using 100mg of Neurofactor
 (Whole coffee fruit extract), and this is the exact dose we are mimicking in our formula for Enhance. 

Neurofactor
 shows some really great promise in increasing plasma levels of BDNF. However, we would love to see studies done on a larger cohort of participants. We would also love to see some studies showing whether this increase in BDNF produced any noticeable improvements in memory scores and other cognitive assessments.

Studies:

  1. https://www.ncbi.nlm.nih.gov/pubmed/23312069
  2. https://www.nutraingredients-usa.com/Product-innovations/NeuroFactor-Increases-Active-Levels-of-Critical-Protein-for-Cognitive-Health

Acteolin - Osmanthus fragrans extract (200mg)

Nootropic effect:
  • Reduces β-amyloid peptide (Aβ) accumulation and abnormal tau protein phosphorylation 
  • Improves cholinergic system in the brain

Summary:

Acteolin by Nulivscience is a proprietary acteoside extracted from Osmanthus fragrans flower.⁣

Studies have shown that this extract is able to support cognitive function by reducing β-amyloid peptide (Aβ) accumulation and abnormal tau protein phosphorylation and by protecting the central cholinergic system in the brain. ⁣

The buildup or accumulation of β-amyloid is implicated in impaired cognitive and memory functions. Evidence suggests this may be a strong marker for Alzheimer's Disease.⁣

A recent study showed that Osmanthus Fragrans Extract, high in acteosides successfully protected against galactose-induced aging in rodents. ⁣

We can't wait to see more human trials for Acteoside based compounds to explicitly determine it's neuroprotective effect and potential to benefit and support healthy aging. The current evidence however points to this being a very promising compound and pathway to prevent neurodegeneration over time.

Studies:

 1. https://nulivscience.com/application/files/6215/5595/1376/1.Inhibition_of_Amyloid_Aggregation_by_Acteoside_a_Phenylethanoid_Glycoside.pdf

2. https://nulivscience.com/application/files/6615/5595/1472/2.Acteoside_protects_human_neuroblastoma_SH-SY5Y_cells_against_beta-amyloid-induced_cell_injury.pdf

3. https://nulivscience.com/application/files/7715/5595/1555/3.Upregulation_of_heme_oxygenase-1_by_acteoside_through_ERK_and_PI3_KAkt_pathway_confer_neuroprotection_against_beta-amyloid-induced_neurotoxicity.pdf

4. https://nulivscience.com/application/files/3015/5595/1633/5.Induction_of_Hepatocyte_Growth_Factor_Production_in_Human_Dermal_fibroblasts_by_caffeic_acid_derivatives.pdf

5. https://nulivscience.com/application/files/2815/5925/1665/2_Inhibitory_Effect_of_Acteoside_Isolated_from_cistanche_ubulosa_on_chemical_mediator_release_and_inflammatory_cytokine_productio.pdf

6. https://nulivscience.com/application/files/8615/5595/2993/4.Acteoside_and_Isoacteoside_Protect_Amyloid_b_Peptide_Induced_Cytotoxicity_Cognitive_Deficit_and_Neurochemical_Disturbances_In_Vitro_and_In_Vivo-compressed.pdf

 

Cellcharge - Fulvic mineral support  (10mg)

Nootropic effect:
  • Micronutrient support
  • Gut health + Absorption
  • Anti-inflammatory

Summary:

Cellcharge is a plant based liquid suspension extremely rich in concentrated polyphenols, flavonoids, organic acids, amino acids, electrolytes and fulvic mineral complexes. ⁣

This is a super potent formula used to enrich your body with essential micronutrients and plant based compounds that a lot of us might not be getting from our regular diets and food sources.⁣

Fulvic acids/minerals are compounds that can be found in and extracted from natural earth deposits and plants or produced via microorganisms in soil.⁣

These compounds may help to improve gut health, reduce inflammation and improve brain function & overall energy levels.⁣

A 2018 review article titled "Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Dieases and Diabetes" concluded that "FvA can act as an immune modulator, influence the redox state, and potentially affect gut health. FvA is shown to decrease proinflammatory markers but also activate the immune system to kill bacteria." ⁣

The review continues to say that evidence seems strong despite minimal research being conducted and some confusion existing around correct dosages. ⁣
⁣This is a really exciting new ingredient that we welcome in Enhance Daily Neurovitamin. The biggest benefits in brain performance and overall health can be seen when we first fix up our nutritional deficiencies before adding other extra compounds. ⁣

Studies:

  1. https://www.researchgate.net/publication/307553680_Medicinal_applications_of_fulvic_acid
  2. https://www.mdpi.com/2504-3900/1/10/1031
  3. https://www.hindawi.com/journals/jdr/2018/5391014/

Bioperine (10mg)

Nootropic effect:
  • Absorption enhancer

Summary:

BioPerine is a patented extract obtained from black pepper fruits standardized minimum to 95% Piperine.⁣

BioPerine is commonly used as an absorption enhancer when utilised with other various compounds.⁣

BioPerine may be co-administered with various nutrients to enhance their bioavailability in both human and animal models.⁣

In general, BioPerine is found to enhance absorption of nutrients by at least 30%.⁣

One particular study, regularly cited, showed that Bioperine when administered with Curcumin, a component of turmeric, increased its bioavailability by 2000%⁣

A huge problem for most herbal compounds, micronutrients and nootropics is bioavailability. Bioperine is one of few compounds clinically shown to aid in absorption of multiple different compounds within the human body. At a low dose of 10mg, you can be sure this is a welcome addition to Enhance Neurovitamin.

Studies:

  1. https://www.ncbi.nlm.nih.gov/pubmed/17987447
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816554/
  3. https://arthritis-research.biomedcentral.com/articles/10.1186/ar2662
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/